C1S

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, C1S RNA expression is significantly associated with the protein abundance of many other proteins, with 25,713 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C1S-associated proteins across cancer lineages are TBC1D2B, VIM_S430, and WIPF1. Each is linked with C1S in more than 9 cancer types. Because this analysis shows association rather than direction, both C1S-to-partner and partner-to-C1S results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1S versus TBC1D2B in OV, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C1S→partner) and Y-score (partner→C1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVTBC1D2B →+0.448+1.468<.001<.001310
GBMVIM_S430 →+1.039+1.211<.001<.00139
OVWIPF1 →+0.508+1.541<.001<.00139
GBMPLCB2 →+0.352+0.855<.001<.00139
GBMRSU1 →+0.417+1.711<.001<.00139
GBMSTAB1 →+0.431+1.053<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 25,713 associations by consensus.

C1S vs TBC1D2B — OV

Per-sample scatter of C1S vs TBC1D2B in OV (Pearson r = 0.47).

Explore this scatter interactively →

Exploration