C1S

Across TCGA patient cohorts, C1S protein abundance is significantly associated with the RNA expression of many other genes, with 17,277 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C1S-associated genes across cancer lineages are SERPINE1, GFPT2, and ADAMTS12. Each is linked with C1S in more than 9 cancer types. Because this analysis shows association rather than direction, both C1S-to-partner and partner-to-C1S results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1S versus SERPINE1 in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1S→partner) and Y-score (partner→C1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINE1 →	+2.180	+0.628	<.001	<.001	3	10
COAD	GFPT2 →	+1.223	+0.492	<.001	<.001	3	10
OV	ADAMTS12 →	+1.591	+0.729	<.001	<.001	3	10
OV	COLEC12 →	+1.076	+0.582	<.001	<.001	3	10
OV	ITGA5 →	+1.395	+0.837	<.001	<.001	3	10
OV	COL6A3 →	+1.773	+0.775	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,277 associations by consensus.

C1S vs SERPINE1 — GBM

Explore this scatter interactively →