C1S

Across TCGA patient cohorts, C1S mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1S-associated genes across cancer lineages are JNK2, MEK1, and C-Raf. Each is linked with C1S in more than 2 cancer types. Because this analysis shows association rather than direction, both C1S-to-partner and partner-to-C1S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by C1S-low versus C1S-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1S→partner) and Y-score (partner→C1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.193	+2.249	.002	.005	3	3
UCEC	MEK1 →	+0.386	+2.058	<.001	<.001	3	3
UCEC	C-Raf →	+0.146	+1.523	.001	.008	3	3
UCEC	14-3-3_beta →	-0.085	-2.780	.008	.003	3	2
UCEC	Gab2 →	+0.251	+1.700	.027	.042	3	2
UCEC	PCNA →	+0.180	+1.807	.009	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK2 by C1S expression — UCEC

Explore this box plot interactively →