C1S

Across TCGA cell cohorts, C1S mutation is significantly associated with the mutation status of many other genes, with 4,319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1S-associated genes across cancer lineages are DOCK2, BAZ1A, and ABCA2. Each is linked with C1S in more than 4 cancer types. Because this analysis shows association rather than direction, both C1S-to-partner and partner-to-C1S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOCK2 grouped by C1S-low versus C1S-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1S→partner) and Y-score (partner→C1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DOCK2 →	+2.975	+3.794	.006	.006	1	5
CNS	BAZ1A →	+6.044	+6.044	.001	.001	1	4
BREAST	ABCA2 →	+3.857	+4.807	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	SLC34A2 →	+4.954	+4.392	.008	.008	1	4
CNS	ROBO3 →	+4.044	+5.000	.008	.008	1	4
CNS	HK3 →	+4.044	+5.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,319 associations by consensus.

DOCK2 by C1S expression — BLOOD_Leukemia

Explore this box plot interactively →