C1q and TNF related 12Genealiases: C1QDC2 · CTRP12 · FAM132A
Q-omics provides the consensus-scored C1QTNF12 profile across patient tissues and cancer cell-line models. C1QTNF12 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, C1QTNF12 is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, C1QTNF12 RNA expression shows 16,196 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight ACC, COAD, and TGCT as cancer lineages where C1QTNF12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C1QTNF12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C1QTNF12 survival associations across molecular data types. C1QTNF12 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C1QTNF12 RNA expression–survival associations across cancer types. High C1QTNF12 expression shows unfavorable associations in ACC, UCEC, LIHC and MESO, but favorable associations in HNSC and THYM. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for C1QTNF12 RNA expression.
This table summarizes C1QTNF12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for C1QTNF12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C1QTNF12 shows lower tumor expression in COAD, KICH and KIRP and higher tumor expression in THCA, LIHC and LUSC. The COAD box plot shows higher C1QTNF12 RNA expression in normal versus tumor tissue (log2 FC = −1.830, t-test p < 0.001).
This table shows molecular features associated with C1QTNF12 in patient tissues and cancer cell lines. In patient samples, C1QTNF12 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, C1QTNF12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and SOFT_TISSUE.
