C1QA

Across TCGA patient cohorts, C1QA mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible C1QA-associated genes across cancer lineages are MIR6085, RNU7-128P, and CCNG2P1. Each is linked with C1QA in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QA-to-partner and partner-to-C1QA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6085 grouped by C1QA-low versus C1QA-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QA→partner) and Y-score (partner→C1QA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR6085 →	+0.542	+5.447	<.001	.005	3	2
LIHC	RNU7-128P →	+1.218	+5.108	<.001	.008	3	2
LIHC	CCNG2P1 →	+0.052	+5.108	<.001	.008	3	2
LIHC	RNU1-17P →	+0.322	+7.169	<.001	<.001	3	2
BLCA	OR11J5P →	+0.059	+7.640	<.001	.009	3	2
LIHC	HMGB1P50 →	+0.219	+5.033	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

MIR6085 by C1QA expression — LIHC

Explore this box plot interactively →