C1QA

Across TCGA pan-cancer cohorts, C1QA RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C1QA data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C1QA RNA is associated with better overall survival. In most high-consensus cancer types, elevated C1QA expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, UVM, and LGG are the cancer types where C1QA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.438	0.251	<.001	87	view →
UVM	DFS	Median	All	0.390	0.823	<.001	63	view →
LGG	OS	Median	All	0.363	0.548	<.001	42	view →
CESC	DFS	Median	II,III,IV	0.858	0.689	.003	38	view →
LUSC	OS	Tertile	II,III,IV	0.303	0.741	.001	38	view →
CHOL	DFS	Median	All	0.603	0.212	.005	31	view →
ACC	OS	Median	IV	0.339	0.893	.001	30	view →
KIRC	DFS	Median	IV	0.229	0.494	.003	28	view →
KIRP	DFS	Tertile	All	0.775	1.000	.009	23	view →
GBM	DFS	Tertile	All	0.206	0.442	.004	18	view →
THYM	OS	Tertile	All	0.764	1.000	.008	16	view →
THCA	DFS	Quartile	IV	1.000	0.485	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C1QA–SKCM (OS)

Open the SKCM breakdown →