C1QA

Across TCGA pan-cancer cohorts, C1QA RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of C1QA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C1QA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C1QA is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where C1QA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1QA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+3.091	<.001	12	view →
COAD	All	III,IV	−1.203	<.001	11	view →
LUAD	Male	II,III,IV	−2.007	<.001	9	view →
KIRP	Male	All	+1.956	<.001	9	view →
LUSC	Male	II,III,IV	−2.276	<.001	8	view →
THCA	All	II,III,IV	+0.954	.001	8	view →
HNSC	Female	All	+1.394	.003	6	view →
STAD	All	II,III,IV	+1.096	.010	4	view →
CHOL	All	II,III,IV	−2.900	.045	2	view →
PAAD	All	All	−2.144	.024	2	view →
LIHC	Male	All	−0.771	.017	2	view →
UCEC	All	All	−0.680	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

C1QA–KIRC

Open the KIRC breakdown →