C1QA

Across TCGA patient cohorts, C1QA mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible C1QA-associated genes across cancer lineages are CD4+ naive T-cells, CD8+ T-cells, and CD8+ Tcm. Each is linked with C1QA in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QA-to-partner and partner-to-C1QA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ naive T-cells grouped by C1QA-low versus C1QA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QA→partner) and Y-score (partner→C1QA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD4+ naive T-cells →	+0.031	+5.142	<.001	.041	3	2
COAD	CD8+ T-cells →	+0.059	+5.142	<.001	.041	3	2
COAD	CD8+ Tcm →	+0.101	+4.917	<.001	.048	3	2
UCEC	DC →	+0.035	+2.444	.001	.026	3	1
UCEC	pDC →	+0.072	+2.839	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD4+ naive T-cells by C1QA expression — COAD

Explore this box plot interactively →