C19orf48

Across TCGA patient cohorts, C19orf48 mutation is significantly associated with the RNA expression of many other genes, with 479 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf48-associated genes across cancer lineages are RNU2-34P, SENP3-EIF4A1, and GGA1. Each is linked with C19orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf48-to-partner and partner-to-C19orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-34P grouped by C19orf48-low versus C19orf48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf48→partner) and Y-score (partner→C19orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU2-34P →	+0.252	+2.977	<.001	.009	3	2
UCEC	SENP3-EIF4A1 →	+0.127	+2.649	.001	.005	3	1
UCEC	GGA1 →	+0.404	+2.606	.003	.006	3	1
UCEC	HSCB →	+0.460	+3.459	.003	.005	3	1
UCEC	ATG4A →	+0.494	+3.218	.004	.009	3	1
UCEC	PSMD7 →	+0.590	+3.345	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 479 associations by consensus.

RNU2-34P by C19orf48 expression — UCEC

Explore this box plot interactively →