C19orf48

Across TCGA pan-cancer cohorts, C19orf48 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C19orf48 data layer compared with 3 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher C19orf48 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C19orf48 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THYM show a favorable association.

LIHC, KIRP, and LUAD are the cancer types where C19orf48 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.460	0.623	<.001	97	view →
KIRP	DFS	Tertile	All	0.798	0.973	<.001	78	view →
LUAD	DFS	Median	All	0.736	0.843	<.001	75	view →
LGG	DFS	Median	All	0.673	0.804	<.001	51	view →
THCA	DFS	Median	II,III,IV	0.537	0.835	<.001	32	view →
KIRC	DFS	Tertile	II,III,IV	0.440	0.619	.009	29	view →
SKCM	OS	Median	All	0.287	0.395	.001	27	view →
KICH	DFS	Quartile	III,IV	0.026	0.811	.004	27	view →
SARC	OS	Median	All	0.424	0.596	.001	24	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →
PAAD	DFS	Quartile	All	0.353	0.629	.005	15	view →
SCLC	DFS	Median	III,IV	0.358	0.698	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C19orf48–LIHC (DFS)

Open the LIHC breakdown →