C19orf18

Across TCGA cell cohorts, C19orf18 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C19orf18-associated genes across cancer lineages are MAGEB4, GSG1L2, and CFHR2. Each is linked with C19orf18 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf18-to-partner and partner-to-C19orf18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by C19orf18-low versus C19orf18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf18→partner) and Y-score (partner→C19orf18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAGEB4 →	+0.046	+4.705	<.001	.003	3	2
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
LARGE_INTESTINE	OR14I1 →	+0.014	+4.415	.001	.007	3	1
LARGE_INTESTINE	HIGD1C →	+0.103	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by C19orf18 expression — BLOOD_Leukemia

Explore this box plot interactively →