C19orf18

Across TCGA pan-cancer cohorts, C19orf18 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of C19orf18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C19orf18 RNA is repressed in tumor relative to normal tissue. In most cancer types C19orf18 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and KIRP are the cancer types where C19orf18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C19orf18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.526	<.001	5	view →
HNSC	Male	II,III,IV	−0.284	.006	4	view →
KIRP	All	All	−0.453	.016	3	view →
STAD	Male	IV	+1.590	.013	2	view →
CHOL	All	All	+1.170	.003	2	view →
PRAD	All	All	+0.448	<.001	2	view →
COAD	Male	All	−0.254	.033	2	view →
THCA	Male	IV	−0.746	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

C19orf18–KICH

Open the KICH breakdown →