C16orf74

Across TCGA patient cohorts, C16orf74 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf74-associated genes across cancer lineages are OR4M1, MIR6728, and RNA5SP528. Each is linked with C16orf74 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf74-to-partner and partner-to-C16orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M1 grouped by C16orf74-low versus C16orf74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf74→partner) and Y-score (partner→C16orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR4M1 →	+0.058	+3.827	.003	.003	3	1
UCEC	MIR6728 →	+0.931	+3.628	.001	.008	3	1
UCEC	RNA5SP528 →	+1.176	+3.001	<.001	.009	3	1
UCEC	RBBP4P3 →	+0.126	+3.622	.002	.005	3	1
UCEC	RNA5SP412 →	+1.088	+3.382	<.001	.004	3	1
UCEC	LINC00706 →	+0.161	+3.109	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

OR4M1 by C16orf74 expression — UCEC

Explore this box plot interactively →