C16orf74

Across TCGA pan-cancer cohorts, C16orf74 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C16orf74 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C16orf74 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C16orf74 expression acts as an unfavorable survival marker, although some lineages such as UVM and THYM show a favorable association.

ACC, UCEC, and COAD are the cancer types where C16orf74 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.345	0.721	<.001	105	view →
UCEC	OS	Median	III,IV	0.754	0.891	<.001	78	view →
COAD	OS	Quartile	II,III,IV	0.774	0.926	<.001	73	view →
PAAD	DFS	Tertile	All	0.161	0.375	<.001	57	view →
SKCM	OS	Tertile	All	0.268	0.435	<.001	57	view →
KIRC	DFS	Tertile	All	0.536	0.729	<.001	56	view →
HNSC	DFS	Tertile	All	0.275	0.526	.001	55	view →
UVM	DFS	Median	All	0.907	0.562	<.001	54	view →
THYM	DFS	Tertile	All	1.000	0.699	<.001	53	view →
LUAD	DFS	Tertile	All	0.737	0.854	.001	41	view →
UCS	OS	Tertile	IV	0.224	0.922	.024	30	view →
KIRP	OS	Tertile	All	0.847	0.540	.002	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C16orf74–ACC (DFS)

Open the ACC breakdown →