C16orf74

Across TCGA pan-cancer cohorts, C16orf74 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C16orf74’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C16orf74 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C16orf74 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where C16orf74 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C16orf74 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.676	<.001	12	view →
KIRC	Male	III,IV	+2.107	<.001	12	view →
LUSC	All	III,IV	+2.269	<.001	8	view →
THCA	Male	IV	−1.943	<.001	8	view →
KIRP	All	All	+0.832	.001	8	view →
LUAD	Male	All	+1.035	<.001	7	view →
BRCA	All	III,IV	+0.603	.027	5	view →
CHOL	All	All	+1.646	.004	4	view →
BLCA	Male	All	+1.612	.043	3	view →
LIHC	All	All	+0.374	.004	3	view →
PRAD	All	All	−1.390	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

C16orf74–HNSC

Open the HNSC breakdown →