C16orf74

Across TCGA cell cohorts, C16orf74 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,273 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C16orf74-associated GO terms across cancer lineages are Blood coagulation, extrinsic pathway, Basophil activation, and Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Each is linked with C16orf74 in more than 8 cancer types. Because this analysis shows association rather than direction, both C16orf74-to-partner and partner-to-C16orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blood coagulation, extrinsic pathway grouped by C16orf74-low versus C16orf74-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf74→partner) and Y-score (partner→C16orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Blood coagulation, extrinsic pathway →	+1.096	+1.999	<.001	<.001	3	9
BLOOD_Leukemia	Basophil activation →	+0.087	+1.193	<.001	.001	3	9
PANCREAS	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure →	+1.302	+1.970	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Cell-substrate adhesion →	+0.075	+1.805	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of oligodendrocyte differentiation →	-0.141	-1.356	.002	<.001	3	8
PANCREAS	Blood coagulation, intrinsic pathway →	+0.372	+2.789	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,273 associations by consensus.

Blood coagulation, extrinsic pathway by C16orf74 expression — OVARY

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