C16orf46

Across TCGA patient cohorts, C16orf46 mutation is significantly associated with the RNA expression of many other genes, with 788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf46-associated genes across cancer lineages are LINC01580, RNU6-706P, and DYNLL1P5. Each is linked with C16orf46 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf46-to-partner and partner-to-C16orf46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01580 grouped by C16orf46-low versus C16orf46-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf46→partner) and Y-score (partner→C16orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01580 →	+0.798	+3.669	.002	.007	3	2
LUSC	RNU6-706P →	+0.384	+4.882	<.001	.005	3	2
COAD	DYNLL1P5 →	+0.334	+6.392	<.001	.001	3	2
SKCM	MTHFD2P5 →	+0.038	+3.490	.001	.008	3	2
SKCM	KRT18P50 →	+0.018	+4.199	<.001	.009	3	2
SKCM	RPL31P41 →	+0.198	+4.328	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 788 associations by consensus.

LINC01580 by C16orf46 expression — SKCM

Explore this box plot interactively →