C16orf46

Across TCGA pan-cancer cohorts, C16orf46 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C16orf46 data layer compared with 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher C16orf46 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C16orf46 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

LUSC, BRCA, and LGG are the cancer types where C16orf46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	All	0.296	0.470	<.001	62	view →
BRCA	OS	Median	All	0.947	0.900	.001	46	view →
LGG	DFS	Tertile	All	0.634	0.821	<.001	43	view →
UCS	DFS	Tertile	II,III,IV	0.623	0.254	.005	36	view →
MESO	OS	Quartile	IV	0.834	0.240	.008	33	view →
BLCA	DFS	Tertile	All	0.173	0.447	.017	33	view →
LIHC	DFS	Tertile	All	0.289	0.460	.011	19	view →
LUAD	DFS	Tertile	IV	0.377	0.855	.019	14	view →
OV	DFS	Tertile	IV	0.414	0.236	.037	12	view →
THYM	DFS	Median	All	0.937	0.793	.005	10	view →
CESC	DFS	Median	IV	0.317	0.651	.030	8	view →
ACC	OS	Median	IV	0.344	0.724	.038	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C16orf46–LUSC (DFS)

Open the LUSC breakdown →