C16orf46

Across TCGA pan-cancer cohorts, C16orf46 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C16orf46’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C16orf46 RNA is repressed in tumor relative to normal tissue. In most cancer types C16orf46 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRP are the cancer types where C16orf46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C16orf46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.400	<.001	11	view →
KICH	Female	II,III,IV	−1.270	<.001	11	view →
KIRP	All	IV	+0.934	<.001	8	view →
COAD	Male	All	+0.696	<.001	8	view →
READ	All	All	+0.728	.002	6	view →
HNSC	Male	All	+0.384	.001	6	view →
KIRC	Male	II,III,IV	−0.277	.002	5	view →
CHOL	Male	All	+0.978	<.001	4	view →
STAD	All	II,III,IV	+0.574	<.001	4	view →
LUAD	All	IV	+0.405	.032	2	view →
PRAD	All	All	+0.253	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

C16orf46–THCA

Open the THCA breakdown →