C16orf46

Across TCGA patient cohorts, C16orf46 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf46-associated genes across cancer lineages are ASNS, FASN, and MEK1. Each is linked with C16orf46 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf46-to-partner and partner-to-C16orf46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by C16orf46-low versus C16orf46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf46→partner) and Y-score (partner→C16orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.467	+2.000	.004	.032	3	2
UCEC	FASN →	+0.401	+3.169	.024	.019	3	1
UCEC	MEK1 →	+0.540	+3.584	.001	.002	3	1
UCEC	Myosin-IIa →	+0.228	+1.881	.008	.031	3	1
UCEC	p27_pT157 →	-0.074	-3.130	.004	.019	3	1
UCEC	PCNA →	+0.222	+2.321	.022	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ASNS by C16orf46 expression — UCEC

Explore this box plot interactively →