C15orf54

Across TCGA patient cohorts, C15orf54 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C15orf54-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and N-Ras. Each is linked with C15orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C15orf54-to-partner and partner-to-C15orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by C15orf54-low versus C15orf54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C15orf54→partner) and Y-score (partner→C15orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.169	+2.000	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.119	-2.880	<.001	.001	3	2
UCEC	N-Ras →	-0.126	-1.349	.002	.037	3	2
UCEC	STAT3_pY705 →	-0.446	-2.087	<.001	.004	3	2
UCEC	ASNS →	+0.324	+1.874	.011	.049	3	2
UCEC	ATM →	-0.519	-3.571	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

C-Raf by C15orf54 expression — UCEC

Explore this box plot interactively →