C15orf54

Across TCGA pan-cancer cohorts, C15orf54 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of C15orf54’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C15orf54 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C15orf54 is over-expressed in tumor, although a few such as KICH and PAAD show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where C15orf54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C15orf54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.054	<.001	12	view →
KIRC	Female	All	+0.266	<.001	11	view →
COAD	All	III,IV	+0.058	<.001	9	view →
THCA	Male	III,IV	+0.125	.001	8	view →
BRCA	All	III,IV	+0.127	<.001	6	view →
STAD	All	All	+0.067	<.001	6	view →
LUAD	All	II,III,IV	+0.302	.005	5	view →
UCEC	All	II,III,IV	+0.120	.001	4	view →
KICH	All	III,IV	−0.041	.004	3	view →
LIHC	All	All	+0.017	<.001	3	view →
PAAD	All	All	−0.145	.039	2	view →
BLCA	All	All	+0.117	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

C15orf54–HNSC

Open the HNSC breakdown →