C15orf54

Across TCGA pan-cancer cohorts, C15orf54 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated C15orf54 data layer compared with 2 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher C15orf54 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C15orf54 expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

SCLC, UVM, and BLCA are the cancer types where C15orf54 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Quartile	II,III,IV	0.262	0.800	.001	41	view →
UVM	OS	Tertile	III,IV	0.227	0.692	.034	27	view →
BLCA	DFS	Tertile	All	0.524	0.648	.008	27	view →
SKCM	OS	Quartile	III,IV	0.993	0.735	.002	24	view →
LGG	OS	Quartile	All	0.815	0.914	.003	22	view →
KIRP	DFS	Quartile	All	0.211	0.830	.003	19	view →
ACC	DFS	Tertile	All	0.188	0.647	.033	19	view →
MESO	DFS	Median	IV	0.499	0.149	<.001	18	view →
UCS	DFS	Median	IV	0.909	0.416	.008	18	view →
HNSC	DFS	Median	IV	0.651	0.502	.012	13	view →
THCA	OS	Median	IV	0.838	0.993	.018	10	view →
DLBC	DFS	Median	II,III,IV	0.554	0.951	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

C15orf54–SCLC (DFS)

Open the SCLC breakdown →