C12orf76

Across TCGA patient cohorts, C12orf76 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf76-associated genes across cancer lineages are EGFR_pY1068, EGFR, and Gab2. Each is linked with C12orf76 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf76-to-partner and partner-to-C12orf76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C12orf76-low versus C12orf76-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf76→partner) and Y-score (partner→C12orf76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.299	-3.169	.010	.019	3	1
UCEC	EGFR →	-0.241	-2.973	.001	.035	3	1
UCEC	Gab2 →	+0.501	+3.321	.002	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.162	-3.169	.039	.019	3	1
UCEC	p21 →	+0.198	+2.820	.027	.035	3	1
UCEC	PDCD4 →	-0.530	-2.312	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by C12orf76 expression — UCEC

Explore this box plot interactively →