C12orf76

Across TCGA pan-cancer cohorts, C12orf76 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C12orf76’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C12orf76 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf76 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where C12orf76 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf76 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.255	<.001	10	view →
HNSC	Male	III,IV	+0.750	<.001	9	view →
LIHC	Female	All	+0.612	<.001	9	view →
THCA	All	III,IV	+0.391	<.001	9	view →
BLCA	All	III,IV	+0.817	<.001	8	view →
KICH	Female	All	−0.849	<.001	7	view →
COAD	All	II,III,IV	+0.350	<.001	7	view →
CHOL	All	All	+1.383	<.001	5	view →
LUAD	Female	II,III,IV	−0.504	.003	3	view →
LUSC	Male	All	−0.313	.001	3	view →
LUAD	All	IV	+1.049	.046	2	view →
KIRP	All	IV	+0.667	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C12orf76–KIRC

Open the KIRC breakdown →