C12orf76

Across TCGA pan-cancer cohorts, C12orf76 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C12orf76 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher C12orf76 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf76 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

MESO, LUAD, and LIHC are the cancer types where C12orf76 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.404	0.729	.001	121	view →
LUAD	OS	Tertile	All	0.891	0.753	<.001	93	view →
LIHC	DFS	Tertile	All	0.441	0.630	<.001	92	view →
ACC	DFS	Tertile	All	0.490	0.822	<.001	64	view →
COAD	OS	Tertile	III,IV	0.663	0.845	.003	44	view →
UVM	DFS	Quartile	III,IV	0.170	0.814	.001	37	view →
KIRC	DFS	Quartile	III,IV	0.487	0.723	.021	30	view →
BRCA	OS	Median	III,IV	0.947	0.859	.003	27	view →
KICH	DFS	Quartile	III,IV	0.315	1.000	.013	15	view →
LGG	OS	Median	All	0.932	0.845	.007	11	view →
THYM	OS	Quartile	All	1.000	0.690	.009	11	view →
UCEC	OS	Quartile	III,IV	0.921	0.785	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C12orf76–MESO (OS)

Open the MESO breakdown →