C12orf50

Across TCGA cell cohorts, C12orf50 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C12orf50-associated genes across cancer lineages are LRRC55, ACSM2B, and C18orf21. Each is linked with C12orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf50-to-partner and partner-to-C12orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC55 grouped by C12orf50-low versus C12orf50-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf50→partner) and Y-score (partner→C12orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC55 →	+0.006	+4.922	<.001	.009	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
LARGE_INTESTINE	C18orf21 →	+0.598	+3.064	.009	.009	3	1
LARGE_INTESTINE	C1orf162 →	+0.339	+3.131	<.001	.008	3	1
LARGE_INTESTINE	C12orf60 →	+0.588	+3.064	.002	.009	3	1
LARGE_INTESTINE	CEP57L1 →	+0.677	+3.082	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

LRRC55 by C12orf50 expression — BLOOD_Leukemia

Explore this box plot interactively →