C12orf50

Across TCGA pan-cancer cohorts, C12orf50 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of C12orf50’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C12orf50 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf50 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

HNSC, BRCA, and THCA are the cancer types where C12orf50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.020	<.001	9	view →
BRCA	All	All	+0.010	.010	6	view →
THCA	Female	All	−0.019	<.001	5	view →
COAD	Female	All	+0.016	.030	3	view →
ESCA	All	II,III,IV	+0.035	.019	2	view →
BLCA	Female	IV	−0.026	.016	2	view →
READ	All	III,IV	+0.025	.037	2	view →
LUAD	All	III,IV	−0.021	.034	2	view →
CHOL	All	All	+0.013	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

C12orf50–HNSC

Open the HNSC breakdown →