C12orf40

Across TCGA patient cohorts, C12orf40 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf40-associated genes across cancer lineages are STAT3_pY705, ER-alpha, and GSK-3_pS9. Each is linked with C12orf40 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf40-to-partner and partner-to-C12orf40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by C12orf40-low versus C12orf40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf40→partner) and Y-score (partner→C12orf40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.290	-1.280	<.001	.049	3	2
SKCM	ER-alpha →	-0.179	-1.807	.019	.026	3	2
SKCM	GSK-3_pS9 →	+0.497	+3.459	.007	.005	3	2
SKCM	IGFBP2 →	-0.486	-1.807	.020	.026	3	2
SKCM	Akt_pT308 →	+0.635	+2.713	.001	.003	3	2
SKCM	Rb_pS807_S811 →	+0.502	+2.321	.004	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

STAT3_pY705 by C12orf40 expression — UCEC

Explore this box plot interactively →