C12orf40

Across TCGA cell cohorts, C12orf40 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C12orf40-associated genes across cancer lineages are MAGEB4, CCDC54, and PPDPFL. Each is linked with C12orf40 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf40-to-partner and partner-to-C12orf40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by C12orf40-low versus C12orf40-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf40→partner) and Y-score (partner→C12orf40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	CCDC54 →	+0.137	+3.736	<.001	.004	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	APOC4 →	+0.064	+4.736	<.001	.009	3	1
LUNG_SCLC	OR13C3 →	+0.097	+4.643	<.001	.004	3	1
LARGE_INTESTINE	OR5M11 →	+0.110	+3.095	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAGEB4 by C12orf40 expression — LARGE_INTESTINE

Explore this box plot interactively →