BZW2

Across TCGA patient cohorts, BZW2 mutation is significantly associated with the RNA expression of many other genes, with 1,297 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BZW2-associated genes across cancer lineages are TBRG1, SKA1, and DONSON. Each is linked with BZW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BZW2-to-partner and partner-to-BZW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBRG1 grouped by BZW2-low versus BZW2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BZW2→partner) and Y-score (partner→BZW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TBRG1 →	+0.337	+3.141	.004	<.001	3	2
UCEC	SKA1 →	+0.817	+3.724	<.001	<.001	3	2
UCEC	DONSON →	+0.504	+3.087	.003	<.001	3	2
UCEC	SLBP →	+0.486	+3.491	.009	.002	3	2
UCEC	SKA3 →	+0.709	+2.180	<.001	.009	3	2
UCEC	CHAF1A →	+0.711	+2.436	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,297 associations by consensus.

TBRG1 by BZW2 expression — UCEC

Explore this box plot interactively →