BZW2

Across TCGA pan-cancer cohorts, BZW2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BZW2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where BZW2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BZW2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, THCA, and LIHC are the cancer types where BZW2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BZW2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.026	<.001	11	view →
THCA	Male	III,IV	−0.584	<.001	10	view →
LIHC	Male	II,III,IV	+1.589	<.001	9	view →
LUAD	Female	III,IV	+1.540	<.001	9	view →
COAD	Female	II,III,IV	+1.088	<.001	9	view →
LUSC	Male	All	+1.379	<.001	8	view →
STAD	Male	II,III,IV	+1.117	<.001	8	view →
HNSC	Male	II,III,IV	+0.554	.002	8	view →
BRCA	All	II,III,IV	+0.979	<.001	6	view →
UCEC	All	All	+0.835	.001	6	view →
CHOL	Male	All	+3.120	<.001	5	view →
KICH	Female	II,III,IV	−0.867	.012	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BZW2–KIRP

Open the KIRP breakdown →