BUB1B

Across TCGA patient cohorts, BUB1B mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUB1B-associated genes across cancer lineages are ACC1, Caspase-7-cleavedD198, and eIF4E. Each is linked with BUB1B in more than 1 cancer types. Because this analysis shows association rather than direction, both BUB1B-to-partner and partner-to-BUB1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by BUB1B-low versus BUB1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1B→partner) and Y-score (partner→BUB1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.328	+1.750	.014	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.598	+2.135	.006	.010	3	2
UCEC	eIF4E →	+0.255	+3.000	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.163	-1.847	<.001	.008	3	1
UCEC	ERK2 →	+0.230	+3.584	.001	.002	3	1
UCEC	GAPDH →	+0.418	+1.700	.034	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ACC1 by BUB1B expression — UCEC

Explore this box plot interactively →