BUB1B

Across TCGA cell cohorts, BUB1B mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible BUB1B-associated genes across cancer lineages are LGI1, OR10T2, and OR10R2. Each is linked with BUB1B in more than 1 cancer types. Because this analysis shows association rather than direction, both BUB1B-to-partner and partner-to-BUB1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by BUB1B-low versus BUB1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1B→partner) and Y-score (partner→BUB1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR10T2 →	+0.730	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.927	+4.551	<.001	.004	3	1
OVARY	GPR12 →	+0.171	+4.029	<.001	.009	3	1
OVARY	CFHR5 →	+0.019	+4.450	<.001	.004	3	1
OVARY	GPX5 →	+0.022	+4.228	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

LGI1 by BUB1B expression — BLOOD_Leukemia

Explore this box plot interactively →