BTNL8

Across TCGA patient cohorts, BTNL8 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTNL8-associated genes across cancer lineages are PCNA, S6_pS240_S244, and Caspase-7-cleavedD198. Each is linked with BTNL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTNL8-to-partner and partner-to-BTNL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BTNL8-low versus BTNL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTNL8→partner) and Y-score (partner→BTNL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.200	+1.459	.004	.012	3	2
UCEC	S6_pS240_S244 →	+0.304	+2.321	.021	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.592	+2.700	.002	.005	3	2
UCEC	Chk2_pT68 →	-0.191	-4.061	.001	<.001	3	2
UCEC	4E-BP1 →	+0.248	+3.459	.004	.005	3	2
UCEC	Cyclin-B1 →	+0.443	+2.222	.015	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by BTNL8 expression — UCEC

Explore this box plot interactively →