BTNL8

Across TCGA pan-cancer cohorts, BTNL8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BTNL8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BTNL8 RNA is repressed in tumor relative to normal tissue. In most cancer types BTNL8 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where BTNL8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BTNL8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.655	<.001	12	view →
THCA	All	IV	−0.782	<.001	11	view →
KIRC	Female	All	+0.299	<.001	11	view →
LUAD	All	III,IV	−1.149	<.001	9	view →
LUSC	Male	All	−1.048	<.001	9	view →
READ	All	All	−3.071	<.001	5	view →
BRCA	All	II,III,IV	−0.087	<.001	4	view →
LIHC	All	All	+0.548	.004	3	view →
UCEC	All	All	−0.137	.036	2	view →
PRAD	All	All	−0.033	.028	2	view →
STAD	All	IV	−2.060	.035	1	view →
KIRP	Male	All	−0.098	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BTNL8–COAD

Open the COAD breakdown →