BTNL8

Across TCGA pan-cancer cohorts, BTNL8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BTNL8 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BTNL8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated BTNL8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and CESC are the cancer types where BTNL8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.859	0.717	<.001	110	view →
SKCM	OS	Median	All	0.396	0.279	<.001	108	view →
CESC	DFS	Median	All	0.679	0.427	<.001	96	view →
LUAD	DFS	Median	IV	0.381	0.817	.002	30	view →
THCA	DFS	Tertile	All	0.909	0.778	.006	19	view →
STAD	OS	Quartile	III,IV	0.206	0.641	.003	18	view →
COAD	DFS	Median	All	0.617	0.411	.011	17	view →
LIHC	OS	Median	All	0.722	0.829	.006	14	view →
TGCT	DFS	Tertile	All	0.673	0.901	.004	12	view →
THYM	OS	Quartile	All	0.879	1.000	.015	12	view →
LUSC	DFS	Median	III,IV	0.453	0.191	.007	12	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BTNL8–KIRC (OS)

Open the KIRC breakdown →