BTBD2

Across TCGA cell cohorts, BTBD2 mutation is significantly associated with the mutation status of many other genes, with 2,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BTBD2-associated genes across cancer lineages are DDX59, KCNH1, and LRP5. Each is linked with BTBD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BTBD2-to-partner and partner-to-BTBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX59 grouped by BTBD2-low versus BTBD2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD2→partner) and Y-score (partner→BTBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DDX59 →	+5.437	+5.437	.003	.003	1	3
BONE	KCNH1 →	+5.437	+5.437	.003	.003	1	3
BONE	LRP5 →	+4.437	+5.000	.007	.007	1	3
BONE	GPR179 →	+4.437	+5.000	.007	.007	1	3
BREAST	KIF20B →	+4.297	+4.857	.009	.009	1	3
BREAST	SETDB1 →	+4.297	+4.857	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,865 associations by consensus.

DDX59 by BTBD2 expression — BONE

Explore this box plot interactively →