BROX

Across TCGA patient cohorts, BROX mutation is significantly associated with the RNA expression of many other genes, with 452 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BROX-associated genes across cancer lineages are RNU6-252P, CFHR2, and RNU6-425P. Each is linked with BROX in more than 2 cancer types. Because this analysis shows association rather than direction, both BROX-to-partner and partner-to-BROX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-252P grouped by BROX-low versus BROX-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BROX→partner) and Y-score (partner→BROX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-252P →	+0.360	+4.588	<.001	.008	3	3
HNSC	CFHR2 →	+0.034	+7.954	<.001	.008	3	2
BLCA	RNU6-425P →	+0.322	+4.588	<.001	.008	3	2
HNSC	USP37P1 →	+0.079	+7.954	<.001	.008	3	2
UCEC	RNU6-451P →	+0.448	+2.579	<.001	.001	3	2
UCEC	RNA5SP451 →	+0.280	+2.852	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 452 associations by consensus.

RNU6-252P by BROX expression — BLCA

Explore this box plot interactively →