BROX

Across TCGA pan-cancer cohorts, BROX RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BROX’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where BROX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BROX is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, LIHC, and KIRP are the cancer types where BROX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BROX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	III,IV	+1.025	<.001	10	view →
LIHC	Male	II,III,IV	+1.422	<.001	9	view →
KIRP	All	II,III,IV	+0.742	<.001	9	view →
KICH	Female	All	−1.226	<.001	7	view →
HNSC	All	All	+0.436	<.001	7	view →
BRCA	All	III,IV	+1.047	<.001	6	view →
LUAD	Male	II,III,IV	+0.876	<.001	6	view →
CHOL	Male	All	+2.498	<.001	5	view →
STAD	All	All	+0.614	<.001	5	view →
LUSC	All	All	+0.394	<.001	5	view →
ESCA	All	II,III,IV	+0.984	.020	3	view →
THCA	All	All	−0.175	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BROX–BLCA

Open the BLCA breakdown →