BRK1

Across TCGA patient cohorts, BRK1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,073 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible BRK1-associated genes across cancer lineages are LINC01119, RIMS3, and RHOA. Each is linked with BRK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRK1-to-partner and partner-to-BRK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRK1 versus LINC01119 in BRCA, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRK1→partner) and Y-score (partner→BRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01119 →	+0.265	+0.198	.005	.003	3	4
HNSC	RIMS3 →	+0.835	+0.169	.001	<.001	3	3
PDAC	RHOA →	+0.304	+0.469	<.001	<.001	3	3
BRCA	FAM126A →	+0.672	+0.235	.001	.002	3	3
GBM	MINDY3 →	+0.474	+0.255	<.001	<.001	3	3
LUAD	CAMK4 →	+0.473	+0.207	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,073 associations by consensus.

BRK1 vs LINC01119 — BRCA

Explore this scatter interactively →