BRD9

Across TCGA cell cohorts, BRD9 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRD9-associated genes across cancer lineages are KCTD8, AADACL2, and OR52E1. Each is linked with BRD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRD9-to-partner and partner-to-BRD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD8 grouped by BRD9-low versus BRD9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD9→partner) and Y-score (partner→BRD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCTD8 →	+0.255	+4.095	<.001	.009	3	2
BLOOD_Leukemia	AADACL2 →	+0.012	+4.922	.003	.009	3	2
STOMACH	OR52E1 →	+0.017	+4.285	<.001	.007	3	1
CNS	C10orf71 →	+0.016	+4.981	<.001	.008	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	GPR101 →	+0.012	+3.990	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KCTD8 by BRD9 expression — LARGE_INTESTINE

Explore this box plot interactively →