BOK

Across TCGA patient cohorts, BOK mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BOK-associated genes across cancer lineages are KRTAP22-1, C11orf24, and RNA5SP414. Each is linked with BOK in more than 1 cancer types. Because this analysis shows association rather than direction, both BOK-to-partner and partner-to-BOK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP22-1 grouped by BOK-low versus BOK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOK→partner) and Y-score (partner→BOK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRTAP22-1 →	+0.102	+4.049	.001	.008	3	2
UCEC	C11orf24 →	+0.518	+3.223	.002	.009	3	1
UCEC	RNA5SP414 →	+0.820	+2.670	<.001	.009	3	1
UCEC	MIR6766 →	+0.334	+3.136	<.001	.008	3	1
UCEC	OR6K6 →	+0.081	+3.136	<.001	.008	3	1
UCEC	CYCSP45 →	+0.317	+3.516	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

KRTAP22-1 by BOK expression — UCEC

Explore this box plot interactively →