BOK

Across TCGA pan-cancer cohorts, BOK RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of BOK’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where BOK RNA is repressed in tumor relative to normal tissue. In most cancer types BOK is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and COAD are the cancer types where BOK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BOK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.364	.003	8	view →
THCA	All	All	−0.527	<.001	8	view →
COAD	Female	All	+1.224	<.001	7	view →
LUSC	Female	All	−1.241	<.001	6	view →
BRCA	All	II,III,IV	−1.117	<.001	6	view →
UCEC	All	II,III,IV	−0.723	.004	6	view →
LUAD	All	All	−0.496	<.001	5	view →
READ	All	III,IV	+0.505	.001	4	view →
HNSC	All	All	+0.363	.016	3	view →
CHOL	Male	All	−0.859	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

BOK–BLCA

Open the BLCA breakdown →