BNIP3P5

Across TCGA pan-cancer cohorts, BNIP3P5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated BNIP3P5 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher BNIP3P5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BNIP3P5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

CESC, LGG, and UCEC are the cancer types where BNIP3P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.157	0.683	<.001	74	view →
LGG	OS	Tertile	All	0.320	0.493	<.001	38	view →
UCEC	DFS	Tertile	All	0.781	0.874	.006	32	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	30	view →
LUAD	OS	Quartile	All	0.686	0.380	.014	24	view →
MESO	DFS	Quartile	All	0.096	0.580	.004	21	view →
KICH	OS	Median	All	0.924	1.000	.013	17	view →
BRCA	DFS	Median	III,IV	0.935	0.823	.003	17	view →
LAML	DFS	Quartile	All	0.778	0.404	.017	12	view →
GBM	DFS	Median	All	0.157	0.278	.016	9	view →
READ	OS	Tertile	IV	0.911	0.428	.008	8	view →
DLBC	DFS	Tertile	All	0.674	0.939	.030	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

BNIP3P5–CESC (DFS)

Open the CESC breakdown →