BNIP3P5

Across TCGA pan-cancer cohorts, BNIP3P5 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of BNIP3P5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where BNIP3P5 RNA is repressed in tumor relative to normal tissue. In most cancer types BNIP3P5 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, HNSC, and LUSC are the cancer types where BNIP3P5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BNIP3P5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.100	<.001	9	view →
HNSC	All	III,IV	+0.305	.001	9	view →
LUSC	Female	All	−1.222	<.001	8	view →
STAD	Male	II,III,IV	+0.243	.009	4	view →
LIHC	Male	All	+0.412	<.001	2	view →
THCA	All	All	+0.166	.042	1	view →
BRCA	All	All	−0.108	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

BNIP3P5–LUAD

Open the LUAD breakdown →