BNIP3L

Across TCGA patient cohorts, BNIP3L mutation is significantly associated with the RNA expression of many other genes, with 6,274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNIP3L-associated genes across cancer lineages are RNF168, HMGB2, and LRRC45. Each is linked with BNIP3L in more than 2 cancer types. Because this analysis shows association rather than direction, both BNIP3L-to-partner and partner-to-BNIP3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF168 grouped by BNIP3L-low versus BNIP3L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP3L→partner) and Y-score (partner→BNIP3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNF168 →	+0.495	+3.459	.001	.005	3	3
UCEC	HMGB2 →	+0.507	+2.269	<.001	<.001	3	3
UCEC	LRRC45 →	+0.332	+1.463	.004	.005	3	3
UCEC	PPM1D →	+0.394	+2.800	<.001	<.001	3	3
UCEC	TYMS →	+0.937	+2.478	<.001	<.001	3	3
UCEC	FAM210A →	+0.447	+2.435	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,274 associations by consensus.

RNF168 by BNIP3L expression — COAD

Explore this box plot interactively →