BNIP3L

Across TCGA patient cohorts, BNIP3L mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNIP3L-associated genes across cancer lineages are FASN, Notch1, and eIF4E. Each is linked with BNIP3L in more than 2 cancer types. Because this analysis shows association rather than direction, both BNIP3L-to-partner and partner-to-BNIP3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by BNIP3L-low versus BNIP3L-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP3L→partner) and Y-score (partner→BNIP3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.470	+2.823	.039	.034	3	3
STAD	Notch1 →	+0.188	+2.828	.041	.035	3	2
UCEC	eIF4E →	+0.198	+1.784	<.001	<.001	3	2
COAD	INPP4B →	-0.418	-3.161	.023	.019	3	2
UCEC	mTOR_pS2448 →	-0.089	-1.489	.035	.025	3	2
UCEC	Annexin_VII →	-0.094	-1.054	.016	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

FASN by BNIP3L expression — STAD

Explore this box plot interactively →