BMP10

Across TCGA patient cohorts, BMP10 mutation is significantly associated with the RNA expression of many other genes, with 1,528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP10-associated genes across cancer lineages are IRGQ, RRM2, and LMNB2. Each is linked with BMP10 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMP10-to-partner and partner-to-BMP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRGQ grouped by BMP10-low versus BMP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP10→partner) and Y-score (partner→BMP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRGQ →	+0.425	+3.491	.001	.002	3	3
UCEC	RRM2 →	+0.842	+2.708	<.001	.003	3	3
UCEC	LMNB2 →	+0.604	+3.095	.001	<.001	3	3
UCEC	ORC1 →	+0.726	+3.721	<.001	<.001	3	3
UCEC	KHSRP →	+0.486	+3.828	<.001	<.001	3	3
UCEC	PRC1 →	+0.582	+2.247	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,528 associations by consensus.

IRGQ by BMP10 expression — UCEC

Explore this box plot interactively →